Aspirin inhibits endometrial fibrosis by suppressing the�TGF‑β1‑Smad2/Smad3 pathway in intrauterine adhesions
نویسندگان
چکیده
منابع مشابه
Progesterone inhibits endometrial cancer invasiveness by inhibiting the TGFβ pathway.
Increased expression of TGFβ isoforms in human endometrial cancer correlates with decreased survival and poor prognosis. Progesterone has been shown to exert a chemoprotective effect against endometrial cancer, and previous animal models have suggested that these effects are accompanied by changes in TGFβ. The goal of this study was to characterize the effect of progesterone on TGFβ signaling p...
متن کاملProgesterone Inhibits Endometrial Cancer Invasiveness by Inhibiting the TGFb Pathway
Increased expression of TGFb isoforms in human endometrial cancer correlates with decreased survival and poor prognosis. Progesterone has been shown to exert a chemoprotective effect against endometrial cancer, and previous animal models have suggested that these effects are accompanied by changes in TGFb. The goal of this study was to characterize the effect of progesterone on TGFb signaling p...
متن کاملEfficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions
The primary purpose of this paper is to assess the efficacy of the use of the intrauterine device (IUD) as an adjunctive treatment modality, for intrauterine adhesions (IUAs). All eligible literatures were identified by electronic databases including PubMed, Scopus, and Web of Science. Additional relevant articles were identified from citations in these publications. There were 28 studies inclu...
متن کاملEndometrial thickness measured by ultrasound scan in women with uterine outlet obstruction due to intrauterine or upper cervical adhesions.
BACKGROUND A subgroup of women with Asherman's syndrome has adhesions of limited extent completely blocking the lower uterine cavity or upper cervix, whereas the upper endometrium remains normal. Haematometra are rarely found in these women. We tested the hypothesis that women with localized adhesions occluding the uterine outlet (but not affecting the upper uterine cavity) will have much thinn...
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Author details Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Department of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Department of Translational Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Biotechnology Program, Zoology Department, Faculty of Science, PS U, Port S...
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ژورنال
عنوان ژورنال: International Journal of Molecular Medicine
سال: 2020
ISSN: 1107-3756,1791-244X
DOI: 10.3892/ijmm.2020.4506